Plasma cell leukemia: from biology to treatment

Chronic lymphocytic leukemia, biology, new diagnosis and treatment: review article

Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...

Hodgkin’s Lymphoma Occurring Secondary to Autologous Stem Cell Transplantation in Plasma Cell Leukemia; A Case Report

Survival of patients with multiple myeloma has improved substantially because of availability of new therapies including autotransplants, immunomodulating drugs and proteasome-inhibitors. Second primary cancers have emerged as an important determinant of morbidity and mortality among cancer survivors. Even though there is an increased risk of new cancers of the lymphoreticular and haematopoetic...

Leptomeningeal metastases from primary plasma cell leukemia.

H ere, we describe a 52-year-old woman with a history of primary plasma cell leukemia (PCL) who achieved complete remission after the tandem of autologous and nonmyeloablative allogeneic stem cell transplantation (SCT). Nine months after the allogeneic SCT, she presented with oculomotor and trochlear nerve palsy (diplopia, ptosis of the right upper eye lid, and dilated right pupil). Physical ex...

Plasma cell leukemia

Paciente do gênero feminino, 74 anos, procurou o hospital com quadro de insuficiência renal e lesões líticas em coluna vertebral, sendo feito diagnóstico de mieloma múltiplo IgG kappa. Na ocasião, observaram-se monossomia do cromossomo 13 e rearranjo do IgH no FISH. A paciente foi submetida a cinco ciclos de VMP (bortezomibe, melfalan e prednisona) com resposta com pleta; foi iniciada a manuten...

Plasma cell leukemia.